Medical Studies Regarding Cannabis

Medical Studies Regarding Cannabis

The Cannabis Research Library is an excellent resource and contains extensive links to medical studies regarding cannabis.

Marijuana Ingredient Inhibits VEGF Pathway Required for Brain Tumor Blood Vessels
Cannabinoids, the active ingredients in marijuana, restrict the sprouting of blood vessels to brain tumors by inhibiting the expression of genes needed for the production of vascular endothelial growth factor (VEGF).
Info on Cannabinoids
Comments: The Cannabinoid System has been around for over 600 million years. Before the Dinosaurs. The Cannabinoid System is continuously evolutioning and has been retained by all new species. Food and feeding is at the heart of the Cannabinoid System.
CANNABIS EXTRACT CUTS URGE ENURESIS IN MS PATIENTS
Treatment with cannabinoids may help prevent urge incontinence in multiple sclerosis ( MS ) patients, investigators said at the joint meeting of the International Continence Society and the International UroGynecological Association.
Delta-9 tetrahydrocannabinol (THC) inhibits lytic replication of gamma oncogenic herpesviruses in vitro
The major psychoactive cannabinoid compound of marijuana delta-9 tetrahydrocannabinol (THC) has been shown to modulate immune responses and lymphocyte function. After primary infection the viral DNA genome of gamma herpesviruses persists in nuclei of lymphoid cells in a latent episomal circular form. In response to extracellular signals, the latent virus can be activated, which leads to production of infectious virus progeny. Therefore, we evaluated potential effects of THC on gamma herpesvirus replication.
Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas
Cannabinoids inhibit tumor angiogenesis in mice, but the mechanism of their antiangiogenic action is still unknown. Because the vascular endothelial growth factor (VEGF) pathway plays a critical role in tumor angiogenesis, here we studied whether cannabinoids affect it. their specific G protein-coupled receptors CB1 and CB2, which are normally engaged by a family of endogenous ligands–the endocannabinoids
PUBLIC HEALTH MARIJUANA: The New Direction in Harm Reduction
When the National Institute on Drug Abuse turned its sights on the mechanism of cannabinols and their endogenous analogues such as anandamide in the brain, they were disappointed to find that the dopamine model they relied on to explain drug abuse and addiction seemed to let cannabis off the hook. The modest uptick in dopamine levels produced by pot confirmed what the old hippies saw, marijuana is pleasurable, but not particularly addictive.
Providing Medical Marijuana: The Importance of Cannabis Clubs
"... the cannabis clubs afford the best therapeutic setting for providing medical cannabis and for offering a healing environment composed of like-minded, sympathetic friends."
Chronic Cannabis Use in the Compassionate Investigational New Drug Program; An Exaimnation of Benefits and Adverse Effects of Legal Clinical Cannabis [requires Acrobat Reader]
The Missoula Chronic Cannabis Use Study was proposed to investigate the therapeutic benefits and adverse effects of the prolonged use of "medical marijuana" in a cohort of seriously ill patients.
Short-Term Effects of Cannabinoids on HIV Viral Load
A study by researchers from the University of California, San Francisco has found that patients with HIV infection taking protease inhibitors do not experience short-term adverse virologic effects from using cannabinoids.
MARIJUANA DOES NOT APPEAR TO ALTER VIRAL LOADS OF HIV PATIENTS TAKING PROTEASE INHIBITORS
Widespread use of smoked marijuana in patients with symptomatic HIV infection in San Francisco prompted this safety study.
Effects of acute smoked marijuana on complex cognitive performance.
Although the ability to perform complex cognitive operations is assumed to be impaired following acute marijuana smoking, complex cognitive performance after acute marijuana use has not been adequately assessed under experimental conditions.
Neuroprotective antioxidants from marijuana.
Cannabidiol and other cannabinoids were examined as neuroprotectants in rat cortical neuron cultures exposed to toxic levels of the neurotransmitter, glutamate.
Neuropsychological performance in long-term cannabis users.
Although cannabis is the most widely used illicit drug in the United States, its long-term cognitive effects remain inadequately studied.
Pneumorachis and pneumomediastinum caused by repeated muller's maneuvers: Complications of marijuana smoking.
Pneumomediastinum may occur during marijuana inhalation but only rarely has pneumorachis (epidural pneumatosis or aerorachia) been reported.
Simultaneous determination of delta9-tetrahydrocannabinol and 11-nor-9-carboxy-delta9-tetrahydrocannabinol in human plasma by solid-phase extraction and gas chromatography-negative ion chemical ionization-mass spectrometry.
Delta9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-delta9-tetrahydrocannabinol (THCA) in human plasma can be simultaneously detected using solid-phase extraction with gas chromatography and negative ion chemical ionization mass spectrometry.
A comparison of Roche Kinetic Interaction of Microparticles in Solution (KIMS) assay for cannabinoids and GC-MS analysis for 11-nor-9-carboxy-delta9-tetrahydrocannabinol.
In this study, we investigated the effectiveness of the Roche Kinetic Interaction of Microparticles in Solution (KIMS) screening assay for cannabinoid metabolites.
The determination of 11-nor-delta9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH) in hair using negative ion gas chromatography-mass spectrometry and high-volume injection.
The determination of 11-nor-delta9-THC-9-carboxylic acid (THC-COOH) in hair specimens at the sensitivity required to detect marijuana users is a difficult analytical problem.
Temporal indication of marijuana use can be estimated from plasma and urine concentrations of delta9-tetrahydrocannabinol, 11-hydroxy-delta9-tetrahydrocannabinol, and 11-nor-delta9-tetrahydrocannabinol-9-carboxylic acid.
Current technology establishes marijuana use based upon detection of the pharmacologically inactive cannabinoid metabolite (11-nor-delta9-carboxy-tetrahydrocannabinol-9-carboxylic acid, THC-COOH) in urine.
Marijuana use among adolescents: trends, patterns, and influences.
This article reviews current marijuana conditions, trends, and influences among adolescents.
The psychoactive ingredient of marijuana induces behavioural sensitization.
Here we describe, for the first time, the occurrence of behavioural sensitization after chronic exposure to Delta9-tetrahydrocannabinol.
[Cannabis consumption and its psychosocial effects in a comparison of different cultures]
Cannabis consumption is a social and cultural phenomenon. It has a specific place in each society, therefore psychotropic effects are judged differently.
Marijuana use in New Zealand, 1990 and 1998.
To examine changes in marijuana use in a metropolitan region and a provincial/rural region in New Zealand between 1990 and 1998.
Cannabinoid receptor agonist WIN 55,212-2 inhibits rat cortical dialysate gamma-aminobutyric acid levels.
The effects of the cannabinoid receptor agonist WIN 55,212-2 (0.1-5 mg/kg i.p.) on endogenous extracellular gamma-aminobutyric acid (GABA) levels in the cerebral cortex of the awake rat was investigated by using microdialysis. WIN 55,212-2 (1 and 5 mg/kg i.p.) was associated with a concentration-dependent decrease in dialysate GABA levels (-16% +/- 4% and -26% +/- 4% of basal values, respectively).
Blind trials of an onsite saliva drug test for marijuana and opiates.
The objective of these clinical trials was to calculate the performance, limit of detection, specificity and sensitivity of a novel, semi-quantitative immunoassay for drugs of abuse in saliva and to determine operator bias when measured blind by four different operators.
Differential effects of delta9-THC on spatial reference and working memory in mice.
Marijuana remains the most widely used illicit drug in the U.S., and recent attention has been given to putative therapeutic uses of marijuana and cannabinoid derivatives. Thus, developing a better understanding of delta9-THC (tetrahydrocannabinol)-induced mnemonic deficits is of critical importance.
Marijuana use and HIV risk among adolescent offenders: the moderating effect of age.
This study examined gender and age as potential moderators of the association between marijuana use and human immunodeficiency virus (HIV) risk among 272 adolescent offenders. METHODS: Analyses were based on biological and self-report measures of both marijuana use and HIV risk.
Differential effects of delta9-THC on spatial reference and working memory in mice.
Marijuana remains the most widely used illicit drug in the U.S., and recent attention has been given to putative therapeutic uses of marijuana and cannabinoid derivatives. Thus, developing a better understanding of delta9-THC (tetrahydrocannabinol)-induced mnemonic deficits is of critical importance.
Identification and quantitation of 11-nor-delta9-tetrahydrocannabivarin-9-carboxylic acid, a major metabolite of delta9-tetrahydrocannabivarin.
After incubation of delta9-tetrahydrocannabivarin with human hepatocytes, a major metabolic product was detected by gas chromatography-mass spectrometry that showed identical retention time and mass spectrum to the synthetic 11-nor-delta9-tetrahydrocannabivarin-9-carboxylic acid (11-nor-delta9-THCV-9-COOH).
Relationship between cannabis use, schizotypal traits, and cognitive function in healthy subjects.
Relationship between cannabis use, schizotypal traits, and cognitive function in healthy subjects. This research examined the relationship between cannabis use and schizotypal features.
Delta 9-tetrahydrocannabinol-induced MAPK/ERK and Elk-1 activation in vivo depends on dopaminergic transmission.
Delta 9-tetrahydrocannabinol-induced MAPK/ERK and Elk-1 activation in vivo depends on dopaminergic transmission. It is now well established that central effects of Delta 9-tetrahydrocannabinol (THC), the main psychoactive component of marijuana, are mediated by CB1 cannabinoid receptors.
Novel physiologic functions of endocannabinoids as revealed through the use of mutant mice.
Novel physiologic functions of endocannabinoids as revealed through the use of mutant mice. The presence in the mammalian brain of specific receptors for marijuana triggered a search for endogenous ligands, several of which have been recently identified.
Effects of cannabinoids in Krox-24 targeted mice.
Effects of cannabinoids in Krox-24 targeted mice. Krox-24 is an immediate early gene encoding a zinc-finger transcription factor implicated in several adaptive responses, and its induction by cannabinoids has been reported.
The role of cannabinoids in neurodegenerative diseases.
The role of cannabinoids in neurodegenerative diseases. An understanding of the actions of Cannabis (Marijuana) has evolved from folklore to science over the previous hundred years. This progression was spurred by the discovery of an endogenous cannabinoid system consisting of two receptors and two endogenous ligands.
Marijuana use and social networks in a community outbreak of meningococcal disease.
We examined the role of social networks and marijuana smoking in a community outbreak of infections due to Neisseria meningitidis.
The pharmacological activity of inhalation exposure to marijuana smoke in mice.
The pharmacological activity of inhalation exposure to marijuana smoke in mice. Although the majority of cannabinoid users smoke marijuana, the preponderance of laboratory animal research is based on administration of Delta9-tetrahydrocannabinol (Delta9-THC) or other cannabinoid agents via injection.
The pharmacological activity of inhalation exposure to marijuana smoke in mice.
Cannabinoids inhibit emesis through cb1 receptors in the brainstem of the ferret. Marijuana and other cannabinoids are effective anti-emetics. Despite ongoing controversy over their usage, the receptor distribution and the site of the anti-emetic action of these compounds are not known.
Delta9-tetrahydrocannabivarin as a marker for the ingestion of marijuana versus Marinol: results of a clinical study.
Delta9-tetrahydrocannabivarin as a marker for the ingestion of marijuana versus Marinol: results of a clinical study. Delta9-tetrahydrocannabinol (THC), the main psychologically active ingredient of the cannabis plant (marijuana), has been prepared synthetically and used as the bulk active ingredient of Marinol, which was approved by the FDA for the control of nausea and vomiting in cancer patients receiving chemotherapy and as an appetite stimulant for AIDS patients.
Proposition 215: a dilemma.
The author describes the scope of California's Proposition 215 and explains the legal and scientific controversies that surround its enactment.
Absence of delta -9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice.
The involvement of dynorphin on Delta-9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene.
Allowing the medical use of cannabis.
Cannabis has been advocated as a treatment for nausea, vomiting, wasting, pain and muscle spasm in cancer, HIV/AIDS, and neurological disorders.
Antiemetic efficacy of smoked marijuana. Subjective and behavioral effects on nausea induced by syrup of ipecac.
Although the public debate about the legalization of marijuana has continued for as long as 25 years, few controlled studies have been conducted to assess its potential medical benefits. The present study examined the antiemetic effect of smoked marijuana cigarettes (8.4 and 16.9 mg Delta(9)-tetrahydrocannabinol [THC]) compared to a highly potent antiemetic drug, ondansetron (8 mg) in 13 healthy volunteers.
Substance use problems reported by college students: combined marijuana and alcohol use versus alcohol-only use.
This study examines the relationships among selected demographic characteristics, alcohol use only, alcohol plus marijuana use and substance-use related problems. Data are from 409 randomly selected undergraduate college students attending a large urban university.
Consumption-related differences in the organization and activation of marijuana expectancies in memory.
Using a methodology that has advanced the study of alcohol expectancies, the authors modeled a semantic network of marijuana expectancies stored in memory.
Alcohol and Marijuana: Effects on Epilepsy and Use by Patients with Epilepsy.
We review the safety of alcohol or marijuana use by patients with epilepsy. Alcohol intake in small amounts (one to two drinks per day) usually does not increase seizure frequency or significantly affect serum levels of antiepileptic drugs (AEDs).
Many epilepsy and multiple sclerosis patients believe marijuana is an effective treatment
Despite limited evidence of effectiveness, many epilepsy and multiple sclerosis patients believe marijuana is an effective treatment and are actively using it, according to two Canadian studies published in the June 8 issue of Neurology, the scientific journal of the American Academy of Neurology.

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